|
|
|
Diabetes Associations
A person with diabetes needs to acquire the necessary education and knowledge about his condition in order to know how to avoid the onset of acute or chronic complications, and to be able to attack and swiftly remedy any problem. This way life can...
Diabetes: Diabetogenic Environments
Western society is referred to as diabetogenic, places where
people have easy access to high fat, high calorie foods and
others, these ones do not have to work hard or to walk to get
this kind of products.
Many doctors suggest that diabetes...
Mortal Diabetes And Its Fatal Types
Diabetes is a disease in which the body does not properly control the amount of sugar in the blood. As a result, the level of sugar in the blood increases. This condition many occurs when the body does not produce enough insulin or does not use it...
One of The Worst Complications of Diabetes May Be Preventable
(ARA) - When Greg Owen was referred to the Ingham Regional Wound Care Center in Lansing, Mich., he was in danger of losing his toe, possibly his foot, to one of the most devastating complications of diabetes -- chronic wounds. As an active member...
What If Low-Carb Diets Can Cure Diabetes and Heart Diseases
Low-carb diets can be advantageous in increased body weight ,
heart disease and treatment of diabetes according to new
clinical studies .
Low carb diets still revolutionize the clinical practice of
nutrition. Many scientists are now...
|
|
| |
|
|
|
|
Combination of Thiazide-Type Diuretic and Beta-Blocker may Cause Diabetes
Clinical Question: In patients with hypertension is it safe to combine thiazide-type diuretic and beta-blocker?
Bottom Line: Studies suggest that the routine combined use of a thiazide with a beta-blocker should be questioned in the early management of hypertension, particularly in patients who are at increased risk of developing new-onset diabetes. In such patients, the increased risk of developing diabetes may exceed the benefit of blood pressure lowering.
Reference: J Hypertens. 2005 Oct;23(10):1777-1781
Study Design: Retrieve randomized control trials and meta-analysis
Synopsis: Recently published trials addressing the pharmacological management of hypertension have reported an increase in new-onset diabetes mellitus when comparing certain older and newer treatment regimens. Thiazide-type diuretics (thiazides) and beta-blockers have been individually implicated, but these drugs are frequently combined, and the magnitude of risk associated with their combined use has not been quantified. So randomized control trials were retrieved that: (i) featured stepped treatment to manage hypertension; (ii) compared initial treatment using a thiazide or beta-blocker (older drug) with an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker or calcium antagonist (newer drug); (iii) assessed cardiovascular outcomes; (iv) reported new-onset diabetes; and (v) provided at least 1-year follow-up. A meta-analysis of available trials indicated that patients exposed to treatment regimens combining thiazides and beta-blockers are at greater risk of developing diabetes than regimens avoiding this combination of drugs (risk ratio for alternative therapy 0.81, 95% confidence interval 0.77-0.86). Current data cannot inform reliably about the risks associated with individual older drugs because of similar overall exposures in patients starting on newer and older drugs.
About the Author
A Certified Family Physician of the Philippine Academy of Family Physician and continue to complete the requirements for Continuing Medical Education in Family Practice. Also a member of the Philippine Medical Informatics Society, Philippine Occupational Health and Safety Inc., and Pangasinan Medical Society.
Faculty Department of Physiology (Medicine) Lyseum- Northwestern University, Dagupan, Pangasinan, Faculty Medical Informatics Lyseu
|
|
|
|
|
|
